Kerry Wood has struck out the most hitters by a rookie in a game, with 20 strikeouts versus the Astros on May 6, 1998.

pitcher most strikeouts by a rookie in a game
Interpreted as:
pitcher most strikeouts by a rookie in a regular-season game
5/6/1998 Wood 9/10/1980 Gullickson 9/1/1906 Coombs 9/13/1936 Feller 5/30/1906 Pfiester 9/1/2022 Strider 9/17/2016 Gray 8/26/1998 Wood 6/14/1995 Nomo 9/17/1984 Gooden 9/12/1984 Gooden 5/1/1955 Score 7/25/1954 Harshman 8/21/1984 Clemens 8/30/1973 Bibby 9/15/1971 Hooton 9/5/1971 Richard 9/10/1969 Wegener 6/18/1967 Wilson 6/7/1967 Nolan 5/26/1957 Drott 9/22/1954 Spooner 8/23/1936 Feller 7/15/1904 Glade 7/31/1901 Hughes 5/18/2024 Gil 8/2/2013 Fernandez 0 2 4 6 8 10 12 14 16 18 20 20 18 18 17 17 16 16 16 16 16 16 16 16 15 15 15 15 15 15 15 15 15 15 15 15 14 14
NAME SO DATE TM OPP DEC GS CG GF SHO SV IP H TBF R ER HR BB IBB HBP WP
Kerry Wood Kerry Wood 20 5/6/1998
CHC CHC
vs
HOU HOU
W 1 1 0 1 0 9.0 1 29 0 0 0 0 0 1 0
Bill Gullickson Bill Gullickson 18 9/10/1980
MON MON
vs
CHC CHC
W 1 1 0 0 0 9.0 4 33 2 2 0 2 0 0 1
Jack Coombs Jack Coombs 18 9/1/1906
PHA PHA
@
BSA BSA
W 1 1 0 0 0 24.0 15 89 1 0 6 1 0
Bob Feller Bob Feller 17 9/13/1936
CLE CLE
vs
PHA PHA
W 1 1 0 0 0 9.0 2 39 2 2 0 9 1 1
Jack Pfiester Jack Pfiester 17 5/30/1906
CHC CHC
vs
SLN SLN
L 1 1 0 0 0 15.0 12 57 4 0 2 0 0
Spencer Strider Spencer Strider 16 9/1/2022
ATL ATL
vs
COL COL
W 1 0 0 0 0 8.0 2 27 0 0 0 0 0 0 0
Jon Gray Jon Gray 16 9/17/2016
COL COL
vs
SDP SDP
W 1 1 0 1 0 9.0 4 31 0 0 0 0 0 0 0
Kerry Wood Kerry Wood 16 8/26/1998
CHC CHC
@
CIN CIN
W 1 0 0 0 0 8.0 3 30 2 1 1 3 0 0 0
Hideo Nomo Hideo Nomo 16 6/14/1995
LAD LAD
@
PIT PIT
W 1 0 0 0 0 8.0 6 33 3 2 0 2 0 1 1
Dwight Gooden Dwight Gooden 16 9/17/1984
NYM NYM
@
PHI PHI
L 1 1 0 0 0 8.0 7 30 2 1 0 0 0 0 1
Dwight Gooden Dwight Gooden 16 9/12/1984
NYM NYM
vs
PIT PIT
W 1 1 0 1 0 9.0 5 32 0 0 0 0 0 0 0
Herb Score Herb Score 16 5/1/1955
CLE CLE
vs
BOS BOS
W 1 1 0 0 0 9.0 4 34 1 1 0 4 0 0 0
Jack Harshman Jack Harshman 16 7/25/1954
CWS CWS
@
BOS BOS
W 1 1 0 0 0 9.0 5 36 2 2 0 5 1 0 0
Roger Clemens Roger Clemens 15 8/21/1984
BOS BOS
vs
KCR KCR
W 1 1 0 0 0 9.0 7 33 1 1 0 0 0 0 0
Jim Bibby Jim Bibby 15 8/30/1973
TEX TEX
vs
MIN MIN
L 1 0 0 0 0 10.2 7 44 5 5 0 6 0 0 0
Burt Hooton Burt Hooton 15 9/15/1971
CHC CHC
@
NYM NYM
W 1 1 0 0 0 9.0 3 32 2 2 1 2 0 0 0
J.R. Richard J.R. Richard 15 9/5/1971
HOU HOU
@
SFG SFG
W 1 1 0 0 0 9.0 7 38 3 2 0 3 0 0 0
Mike Wegener Mike Wegener 15 9/10/1969
MON MON
@
NYM NYM
1 0 0 0 0 11.0 5 45 2 0 0 7 1 0 0
Don Wilson Don Wilson 15 6/18/1967
HOU HOU
vs
ATL ATL
W 1 1 0 1 0 9.0 0 30 0 0 0 3 0 0 0
Gary Nolan Gary Nolan 15 6/7/1967
CIN CIN
vs
SFG SFG
1 0 0 0 0 7.2 8 31 3 3 1 0 0 0 0
Dick Drott Dick Drott 15 5/26/1957
CHC CHC
vs
MIL MIL
W 1 1 0 0 0 9.0 7 37 5 4 2 1 0 0 0
Karl Spooner Karl Spooner 15 9/22/1954
BKN BKN
vs
NYG NYG
W 1 1 0 1 0 9.0 3 34 0 0 0 3 0 0 0
Bob Feller Bob Feller 15 8/23/1936
CLE CLE
vs
SLA SLA
W 1 1 0 0 0 9.0 6 37 1 1 0 4 0 1
Fred Glade Fred Glade 15 7/15/1904
SLA SLA
@
WSH WSH
W 1 1 0 0 0 9.0 7 39 2 1 0 0 2 0
Tom Hughes Tom Hughes 15 7/31/1901
CHO CHO
@
CIN CIN
L 1 1 0 0 0 13.2 13 58 5 5 0 6 0 1
Unlock 2x data
Results may be incomplete. StatMuse has complete game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.

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