Kyrie Irving has put up his most career points per game against the Rockets, with 28.1 per game.

kyrie irving highest career ppg by opponent

OPP	PPG	GP	MPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	PTS	REB	AST	STL	BLK	TOV	PF	+/-
Rockets	28.1	19	36.6	4.1	6.2	1.0	0.5	3.4	9.4	19.9	47.0	3.2	7.7	40.8	6.2	6.7	91.4	696	533	77	117	19	9	64	49	+25
Pelicans	27.6	21	35.9	4.0	6.2	1.3	0.3	2.6	9.7	20.8	46.8	3.2	7.9	40.4	5.0	5.4	92.1	753	580	83	130	27	7	54	42	+31
Grizzlies	26.9	18	35.3	4.2	5.4	1.4	0.6	3.3	9.6	19.1	50.3	2.8	6.6	42.4	4.9	5.8	84.6	635	484	76	98	26	11	59	52	+47
Mavericks	26.5	15	35.6	3.4	4.9	1.5	0.9	3.1	10.0	20.9	47.9	2.6	7.0	37.1	3.9	4.3	92.2	534	398	51	73	22	13	46	33	+64
Hawks	26.3	33	35.5	4.2	5.7	1.6	0.5	2.8	9.8	19.4	50.6	2.9	6.9	42.7	3.7	4.2	87.1	1,172	867	139	187	53	17	94	66	+36
Knicks	26.0	30	34.8	4.0	6.2	1.3	0.1	2.5	9.4	19.6	47.7	2.8	7.2	38.7	4.4	5.1	86.9	1,044	779	121	186	40	4	74	65	+137
Cavaliers	25.4	11	34.9	4.7	5.5	1.1	0.7	2.3	9.9	19.2	51.7	3.3	7.3	45.0	2.3	2.8	80.6	384	279	52	60	12	8	25	29	+70
Bucks	24.9	34	35.9	4.4	5.6	1.3	0.4	2.9	9.0	19.0	47.6	2.3	5.8	39.1	4.5	4.9	91.7	1,221	845	148	192	45	15	97	78	+81
Trail Blazers	24.4	17	33.5	3.9	4.7	1.5	0.3	2.0	9.3	20.5	45.3	2.8	6.9	40.2	3.0	3.2	94.4	570	414	67	80	26	5	34	33	-17
Nuggets	24.2	19	35.4	3.6	6.3	1.7	0.7	2.1	9.2	18.9	48.6	2.5	6.1	40.5	3.3	3.6	91.3	672	460	69	119	32	13	40	53	-1
Wizards	24.2	31	34.3	3.6	5.9	0.9	0.5	2.8	8.6	18.6	46.0	2.0	5.8	34.3	5.0	5.7	88.1	1,065	749	113	184	29	15	87	68	+102
Jazz	24.1	23	34.6	4.9	5.7	1.6	0.3	1.7	9.0	19.5	46.3	2.5	6.3	39.6	3.5	4.1	86.2	795	554	112	131	36	7	39	56	+99
Lakers	24.0	23	34.3	4.6	5.7	1.3	0.3	2.4	9.0	18.2	49.3	2.5	6.4	39.5	3.5	4.0	89.0	788	551	106	130	31	6	56	58	+44
Magic	23.8	26	33.8	4.5	5.9	1.3	0.3	2.0	8.9	17.6	50.8	2.0	5.1	39.4	3.9	4.5	86.4	879	618	116	154	34	9	53	46	+230
Kings	23.6	22	35.8	3.4	5.7	1.2	0.5	2.5	8.7	18.8	46.5	2.9	6.8	43.0	3.2	4.0	81.6	788	519	74	126	27	10	54	56	+108
Celtics	23.3	26	35.2	3.9	5.0	1.2	0.5	2.4	8.7	18.1	48.0	2.1	5.6	37.0	3.8	4.3	88.5	915	606	102	130	32	12	63	64	-38
Warriors	23.3	22	35.5	4.7	5.7	1.8	0.3	2.8	8.2	18.2	44.9	2.4	5.7	41.3	4.5	5.1	89.3	781	512	104	126	39	7	61	49	+63
Timberwolves	23.2	18	33.6	4.9	5.9	1.3	0.6	3.2	8.9	19.2	46.7	2.3	6.3	36.0	3.0	3.3	91.5	604	417	89	106	23	11	58	48	+25
Pistons	23.2	32	32.7	4.3	5.8	1.3	0.3	2.9	8.3	17.1	48.5	2.3	5.6	41.1	4.2	4.6	91.8	1,046	741	137	184	42	8	94	76	+65
Thunder	22.9	16	34.4	3.9	6.9	1.4	0.4	2.4	9.1	17.8	51.1	2.1	5.1	40.2	2.7	3.3	82.7	551	366	63	111	23	6	38	34	+67
Suns	22.9	20	33.9	3.9	5.8	1.6	0.3	3.3	8.3	17.6	47.0	2.4	5.8	40.9	4.0	4.2	96.4	677	457	77	116	32	6	66	42	+24
Clippers	22.8	17	31.9	3.7	5.1	0.9	0.3	2.4	7.9	16.9	46.9	2.7	5.9	45.5	4.2	4.5	94.7	542	388	63	87	15	5	40	42	+43
Spurs	22.7	22	34.0	3.2	5.2	1.5	0.3	1.8	9.1	18.4	49.4	2.4	5.5	44.2	2.1	2.5	85.5	749	500	70	114	34	7	40	50	+22
Hornets	22.5	34	33.3	4.2	6.2	1.3	0.7	2.3	8.4	17.2	48.8	2.2	5.9	37.2	3.5	4.2	83.9	1,132	766	144	211	44	24	78	79	+184
Pacers	22.5	36	33.8	3.7	5.2	1.0	0.5	2.3	8.3	17.2	48.1	1.9	5.3	34.9	4.1	4.5	90.2	1,216	810	134	186	36	18	81	85	+82