Viatris (VTRS) had the highest return in 1981 by a US stock in the S&P 500 (GSPC), returning 104.5%.

best performing sandp stocks 1981
ASSET YEAR % RETURN
Viatris (VTRS) 1981 104.54%
Home Depot (HD) 1981 66.67%
Sysco (SYY) 1981 47.36%
PNC Financial Services (PNC) 1981 46.83%
Hasbro (HAS) 1981 43.7%
Consolidated Edison (ED) 1981 41.96%
FedEx (FDX) 1981 41.24%
Walmart (WMT) 1981 41.04%
Lockheed Martin (LMT) 1981 39.04%
McDonald’s (MCD) 1981 36.19%
Aon (AON) 1981 36.18%
General Mills (GIS) 1981 32.28%
American International (AIG) 1981 29.5%
Marathon Oil (MRO) 1981 28.53%
Kroger (KR) 1981 28.05%
Bank of New York Mellon (BK) 1981 23.35%
WEC Energy (WEC) 1981 23.17%
Procter & Gamble (PG) 1981 23.13%
CSX (CSX) 1981 21.46%
PulteGroup (PHM) 1981 16.17%
PG&E (PCG) 1981 15.03%
Colgate-Palmolive (CL) 1981 14.51%
Johnson & Johnson (JNJ) 1981 14.51%
Duke Energy (DUK) 1981 13.79%
Dominion Energy (D) 1981 11.91%

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